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Article

Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the <i>UDP glucuronosyltransferase 1</i> ( <i>UGT1</i> ) locus

1 Mar 2010

Abstract excerpt

High levels of unconjugated bilirubin (UCB) in newborn children is associated with a reduction in hepatic UDP glucuronosyltransferase (UGT) 1A1 activity that can lead to CNS toxicity, brain damage, and even death. Little is known regarding those events that lead to UCB accumulation in brain tissue, and therefore, we sought to duplicate this condition in mice. The human UGT1 locus, encoding all 9-UGT1A genes...

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PMID: 20194756
DOI: 10.1073/pnas.0913290107

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