Article
A genome-wide linkage analysis in 181 German sarcoidosis families using clustered biallelic markers.
Chest - 1 Jul 2010
Fischer Annegret, Nothnagel Michael, Schürmann Manfred, Müller-Quernheim Joachim, Schreiber Stefan, Hofmann Sylvia
Abstract excerpt
BACKGROUND: Sarcoidosis (SA) is a systemic granulomatous inflammatory disorder with complex etiology and strong clustering in families. Genome-wide association studies have been successful in the identification of common risk variants for the disease. To reveal susceptibility variants with low frequencies but strong effects, we performed a genome-wide linkage scan in a large sample of SA families. METHODS: We...
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