Article
Phenotypic effect of mutations in evolving populations of RNA molecules.
BMC evolutionary biology - 17 Feb 2010
Stich Michael, Lázaro Ester, Manrubia Susanna C
Abstract excerpt
BACKGROUND: The secondary structure of folded RNA sequences is a good model to map phenotype onto genotype, as represented by the RNA sequence. Computational studies of the evolution of ensembles of RNA molecules towards target secondary structures yield valuable clues to the mechanisms behind adaptation of complex populations. The relationship between the space of sequences and structures, the organization of...
Topics
- Evolution, Molecular
- Genetic Fitness
- Mutation
- Nucleic Acid Conformation
- Phenotype
- RNA
- Selection, Genetic