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Article

Role of sperm αvβ3 integrin in mouse fertilization

11 Feb 2010

Abstract excerpt

Oocyte integrins have been described as essential for fertilization. But this concept has been challenged by deletion experiments. Recently, we have shown that sperm integrin alpha6beta1 plays a determinant role in mouse gamete interaction. In this study, we demonstrate the presence of alphavbeta3 integrin by Western blot and immunofluorescence on the sperm membrane. Oocytes and/or sperm preincubations with...

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PMID: 20151413
DOI: 10.1002/dvdy.22206

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