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Article

POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders.

Seizure - 1 Apr 2010

Saneto Russell P, Lee Inn-Chi, Koenig Mary Kay, Bao Xinhua, Weng Shao-Wen, Naviaux Robert K, Wong Lee-Jun C

Abstract excerpt

PURPOSE: To review our clinical experience and determine if there are appropriate signs and symptoms to consider POLG sequencing prior to valproic acid (VPA) dosing in patients with seizures. METHODS: Four patients who developed VPA-induced hepatotoxicity were examined for POLG sequence variations. A subsequent chart review was used to describe clinical course prior to and after VPA dosing. RESULTS: Four patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20138553
DOI: 10.1016/j.seizure.2010.01.002
PMCID: PMC3099441

Genes

POLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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