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Article

HyperIgE in hypomorphic recombination-activating gene defects.

Current opinion in immunology - 1 Feb 2023

Castiello Maria Carmina, Brandas Chiara, Capo Valentina, Villa Anna

Abstract excerpt

Increased immunogloblulin-E (IgE) levels associated with eosinophilia represent a common finding observed in Omenn syndrome, a severe immunodeficiency caused by decreased V(D)J recombination, leading to restricted T- and B-cell receptor repertoire. V(D)J recombination is initiated by the lymphoid-restricted recombination-activating gene (RAG) recombinases. The lack of RAG proteins causes a block in lymphocyte...

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Identifiers

PMID: 36529093
DOI: 10.1016/j.coi.2022.102279

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