Article
[Molecular markers of Plasmodium falciparum drug resistance].
Medecine tropicale : revue du Corps de sante colonial - 1 Dec 2009
Eboumbou Moukoko E C, Bogreau H, Briolant S, Pradines B, Rogier C
Abstract excerpt
The main Plasmodium falciparum genes known to be associated with drug resistance are pfcrt, pfmdr1, pfdhfr pfdhps, pfcytb, pfmrp, pfnhe1, pfmdt, pfserca and pftetQ. Molecular markers for resistance to chloroquine, amodiaquine, mefloquine, sulfadoxine-pyrimethamine, cycloguanil and atovaquone have been validated and used to predict the parasitological and clinical efficacy of these drugs (i.e. based on in vivo...
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