Article
Common apolipoprotein E gene mutations contribute to lipoprotein glomerulopathy in China.
Nephron. Clinical practice - 1 Jan 2010
Han Jia, Pan Yongli, Chen Yuqing, Li Xia, Xing Guangqun, Shi Junhua, Hou Ping, Zhang Hong, Wang Haiyan
Abstract excerpt
BACKGROUND: Lipoprotein glomerulopathy (LPG) is a unique disease characterized by thrombus-like lipoprotein deposition in glomeruli and an increased serum apolipoprotein E level (ApoE protein or APOE gene). Several APOE mutations contribute to the occurring of LPG. METHODS: We confirmed LPG in 7 individuals by renal biopsy, and investigated families of 2 patients with urinalysis, serum creatinine and serum lipid...
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