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Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview

21 Jan 2010

Abstract excerpt

Macroautophagy is a vacuolar degradation pathway that terminates in the lysosomal compartment after formation of a cytoplasmic vacuole or autophagosome that engulfs macromolecules and organelles. The identification of ATG (autophagy-related) genes that are involved in the formation of autophagosomes has greatly increased our knowledge of the molecular basis of macroautophagy, and its roles in cell function, which...

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PMID: 20089931
DOI: 10.1152/ajpcell.00507.2009

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