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Article

Microphthalmia in Texel sheep is associated with a missense mutation in the paired-like homeodomain 3 (PITX3) gene.

PloS one - 13 Jan 2010

Becker Doreen, Tetens Jens, Brunner Adrian, Bürstel Daniela, Ganter Martin, Kijas James, Drögemüller Cord

Abstract excerpt

Microphthalmia in sheep is an autosomal recessive inherited congenital anomaly found within the Texel breed. It is characterized by extremely small or absent eyes and affected lambs are absolutely blind. For the first time, we use a genome-wide ovine SNP array for positional cloning of a Mendelian trait in sheep. Genotyping 23 cases and 23 controls using Illumina's OvineSNP50 BeadChip allowed us to localize the...

Read the complete abstract on PubMed

Topics

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Share to Chromosomes, Artificial, Bacterial
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeodomain Proteins

Share to Microphthalmos

Share to Mutation, Missense

Share to Polymerase Chain Reaction

Share to Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 20084168
DOI: 10.1371/journal.pone.0008689
PMCID: PMC2805710

Genes

PITX3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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