Article
Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteable.
Molecular and cellular biology - 1 Mar 2010
Vural Ali, Oner Sadik, An Ningfei, Simon Violaine, Ma Dzwokai, Blumer Joe B, Lanier Stephen M
Abstract excerpt
AGS3, a receptor-independent activator of G-protein signaling, is involved in unexpected functional diversity for G-protein signaling systems. AGS3 has seven tetratricopeptide (TPR) motifs upstream of four G-protein regulatory (GPR) motifs that serve as docking sites for Gialpha-GDP. The position...
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