Article
Infrequent amplification of JUN in hepatocellular carcinoma.
Anticancer research - 1 Dec 2009
Endo Mio, Yasui Kohichiroh, Nakajima Tomoaki, Gen Yasuyuki, Tsuji Kazuhiro, Dohi Osamu, Zen Keika, Mitsuyoshi Hironori, Minami Masahito, Itoh Yoshito, Taniwaki Masafumi, Tanaka Shinji, Arii Shigeki, Okanoue Takeshi, Yoshikawa Toshikazu
Abstract excerpt
AIM: To determine whether JUN (the oncogene encoding c-Jun protein) is amplified and overexpressed in hepatocellular carcinoma (HCC). MATERIALS AND METHODS: DNA copy number aberrations were investigated using a high-density oligonucleotide microarray. DNA copy numbers were determined by fluorescence in situ hybridization. Genomic DNA and mRNA were quantified using real-time quantitative PCR. RESULTS: A novel...
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