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Eribulin Binds at Microtubule Ends to a Single Site on Tubulin To Suppress Dynamic Instability

23 Dec 2009

Abstract excerpt

Eribulin mesylate (E7389), a synthetic analogue of the marine natural product halichondrin B, is in phase III clinical trials for the treatment of cancer. Eribulin targets microtubules, suppressing dynamic instability at microtubule plus ends through an inhibition of microtubule growth with little or no effect on shortening [Jordan, M. A., et al. (2005) Mol. Cancer Ther. 4, 1086-1095]. Using [(3)H]eribulin, we...

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PMID: 20030375
DOI: 10.1021/bi901810u

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Related research

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Research trail→

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Eribulin Binds at Microtubule Ends to a Single Site on Tubulin To Suppress Dynamic InstabilityPMID 20030375Read ↗

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