Article
Effect of passaging on Mer phenotype of human fetal cell cultures.
Mutation research - 1 Mar 1991
Day R S, Honore L H, Dobler K D
Abstract excerpt
With increasing passage in culture, the human fibroblast cell strain GM11 lost the Mer+ phenotype (the ability to support the growth of adenovirus 5 damaged prior to infection by MNNG). All of 46 embryonic strains prepared either from various organs of 20 fetuses from 6-7 to 13-14 weeks of gestational age or from two hydatidiform moles showed normal repair of MNNG-treated virus. We conclude that human fetal...
Topics
- Adenoviruses, Human
- Cells, Cultured
- DNA Repair
- Female
- Fetus
- Humans
- Hydatidiform Mole
- In Vitro Techniques
- Methylnitronitrosoguanidine
- Mutation
- Pregnancy
- Uterine Neoplasms