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Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies.

NeuroImage - 15 Nov 2010

Winkler Anderson M, Kochunov Peter, Blangero John, Almasy Laura, Zilles Karl, Fox Peter T, Duggirala Ravindranath, Glahn David C

Abstract excerpt

Choosing the appropriate neuroimaging phenotype is critical to successfully identify genes that influence brain structure or function. While neuroimaging methods provide numerous potential phenotypes, their role for imaging genetics studies is unclear. Here we examine the relationship between brain volume, grey matter volume, cortical thickness and surface area, from a genetic standpoint. Four hundred and...

Topics

Adult
Aged
Aged, 80 and over
Brain
Brain Mapping
Female
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pedigree

Phenotype

Quantitative Trait, Heritable

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Open in PubMed Open full text

Identifiers

PMID: 20006715
DOI: 10.1016/j.neuroimage.2009.12.028
PMCID: PMC2891595

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