Mechanism of action of psoralens: isobologram analysis reveals that ultraviolet light potentiation of psoralen action is not additive but synergistic.

doi:10.1007/BF00685118

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Article

Mechanism of action of psoralens: isobologram analysis reveals that ultraviolet light potentiation of psoralen action is not additive but synergistic.

Cancer chemotherapy and pharmacology - 1 Jan 1991

Yurkow E J, Laskin J D

Abstract excerpt

The combination of psoralens and ultraviolet light (UVA, 320-400 nm), referred to as PUVA, inhibits proliferation of a variety of cell types. In the present studies, we used S-180 cells to investigate the mechanism underlying the antiproliferative actions of PUVA. We found that inhibition of grow...

Topics

Animals
Cell Division
Cell Survival
DNA
Furocoumarins
Mice
Mutation
PUVA Therapy
Tumor Cells, Cultured

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