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Article

Decreased sigmoidal ABCB1 (P-glycoprotein) expression in ulcerative colitis is associated with disease activity.

Pharmacogenomics - 1 Dec 2009

Ufer Mike, Häsler Robert, Jacobs Gunnar, Haenisch Sierk, Lächelt Sandra, Faltraco Frank, Sina Christian, Rosenstiel Philip, Nikolaus Susanna, Schreiber Stefan, Cascorbi Ingolf

Abstract excerpt

AIMS: The modulation of the intestinal expression of detoxifying proteins by relevant transcription factors, intracellular receptors and cytokines in ulcerative colitis (UC) is poorly understood. Here, we compared the intestinal expression of drug transporters, metabolizing enzymes and putative regulatory genes between inflamed and noninflamed tissue and studied their modulation by disease activity. MATERIALS &...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19958093
DOI: 10.2217/pgs.09.128

Genes

ABCB1
DEFA5
DEFA6
HAMP
NAT1
SPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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