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Genetics and intermediate phenotypes of the schizophrenia--bipolar disorder boundary.

Neuroscience and biobehavioral reviews - 1 May 2010

Ivleva Elena I, Morris David W, Moates Amanda F, Suppes Trisha, Thaker Gunvant K, Tamminga Carol A

Abstract excerpt

Categorization of psychotic illnesses into schizophrenic and affective psychoses remains an ongoing controversy. Although Kraepelinian subtyping of psychosis was historically beneficial, modern genetic and neurophysiological studies do not support dichotomous conceptualization of psychosis. Evidence suggests that schizophrenia and bipolar disorder rather present a clinical continuum with partially overlapping...

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PMID: 19954751
DOI: 10.1016/j.neubiorev.2009.11.022

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