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Article

Guanylate cyclases and associated activator proteins in retinal disease.

Molecular and cellular biochemistry - 1 Jan 2010

Hunt David M, Buch Prateek, Michaelides Michel

Abstract excerpt

Two isoforms of guanylate cyclase, GC1 and GC2 encoded by GUCY2D and GUCY2F, are responsible for the replenishment of cGMP in photoreceptors after exposure to light. Both are required for the normal kinetics of photoreceptor sensitivity and recovery, although disease mutations are restricted to GUCY2D. Recessive mutations in this gene cause the severe early-onset blinding disorder Leber congenital amaurosis...

Topics

Animals
Guanylate Cyclase
Guanylate Cyclase-Activating Proteins
Humans
Mutation
Retinal Diseases

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 19941038
DOI: 10.1007/s11010-009-0331-y

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Guanylate cyclases and associated activator proteins in retinal disease.PMID 19941038Read ↗

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