Article
A dominant mutation in mediator of paramutation2, one of three second-largest subunits of a plant-specific RNA polymerase, disrupts multiple siRNA silencing processes.
PLoS genetics - 1 Nov 2009
Sidorenko Lyudmila, Dorweiler Jane E, Cigan A Mark, Arteaga-Vazquez Mario, Vyas Meenal, Kermicle Jerry, Jurcin Diane, Brzeski Jan, Cai Yu, Chandler Vicki L
Abstract excerpt
Paramutation involves homologous sequence communication that leads to meiotically heritable transcriptional silencing. We demonstrate that mop2 (mediator of paramutation2), which alters paramutation at multiple loci, encodes a gene similar to Arabidopsis NRPD2/E2, the second-largest subunit of plant-specific RNA polymerases IV and V. In Arabidopsis, Pol-IV and Pol-V play major roles in RNA-mediated silencing and...
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