Article
Genetic control of the immune response in mice to Leishmania mexicana surface protease.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1991
López J A, Reins H A, Etges R J, Button L L, McMaster W R, Overath P, Klein J
Abstract excerpt
Congenic mouse strains were tested in the lymphocyte proliferation assay for their response to the purified surface protease of Leishmania mexicana (gp63). The data obtained allow us to distinguish three different patterns of response, influenced both by H-2 (class II) and non-H-2 genes. Mice of the C57BL/10 (B10) background carrying H-2 haplotypes b,q, and r were found to be high responders; those carrying H-2...
Topics
- Alleles
- Animals
- Antigens, Protozoan
- Genetic Predisposition to Disease
- H-2 Antigens
- Immunity, Cellular
- Leishmania mexicana
- Leishmaniasis
- Lymphocyte Activation
- Metalloendopeptidases
- Mice