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Article

Panel of prototypical raltegravir-resistant infectious molecular clones in a novel integrase-deleted cloning vector.

Antimicrobial agents and chemotherapy - 1 Feb 2010

Reuman Elizabeth C, Bachmann Michael H, Varghese Vici, Fessel W Jeffrey, Shafer Robert W

Abstract excerpt

We created an HIV-1 cloning vector, pNL4.3DeltaIN, to generate recombinant infectious molecular clones for analysis of patient-derived HIV-1 integrase coding regions. Using this vector, we constructed a panel of clinically derived viruses with the canonical patterns of raltegravir resistance mutations and submitted the panel to the NIH AIDS Research and Reference Reagent Program. Investigational integrase...

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Identifiers

PMID: 19917747
DOI: 10.1128/AAC.01345-09
PMCID: PMC2812164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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