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Article

In vivo transplantation of genetically modified mouse embryonic epidermis.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2010

Martínez-Cruz Ana Belén, Costa Clotilde, Saiz Cristina, Paramio Jesús M, Santos Mirentxu

Abstract excerpt

Situations in which epidermal mutant mice display early lethality after birth are rather frequent. This condition precludes any kind of analysis of adult or even newborn mice tissues. We propose the in vivo embryonic skin transplantation as an alternative to solve this problem. This method allows the generation of a stable epidermal tissue that mimics the specific mutant adult epidermis. It also reproduces the...

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PMID: 19908016
DOI: 10.1007/978-1-60761-380-0_25

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