Human von Willebrand factor gene and pseudogene: structural analysis and differentiation by polymerase chain reaction.

doi:10.1021/bi00215a036

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Article

Human von Willebrand factor gene and pseudogene: structural analysis and differentiation by polymerase chain reaction.

Biochemistry - 8 Jan 1991

Mancuso D J, Tuley E A, Westfield L A, Lester-Mancuso T L, Le Beau M M, Sorace J M, Sadler J E

Abstract excerpt

Structural analysis of the von Willebrand factor gene located on chromosome 12 is complicated by the presence of a partial unprocessed pseudogene on chromosome 22q11-13. The structures of the von Willebrand factor pseudogene and corresponding segment of the gene were determined, and methods were developed for the rapid differentiation of von Willebrand factor gene and pseudogene sequences. The pseudogene is 21-29...

Topics

Amino Acid Sequence
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 22
Cloning, Molecular
Exons
Genes
Genetic Variation
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Hybridization

Oligonucleotide Probes

Plasmids

Polymerase Chain Reaction

Pseudogenes

Repetitive Sequences, Nucleic Acid

Restriction Mapping

Source

Open in PubMed

Identifiers

PMID: 1988024
DOI: 10.1021/bi00215a036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1988024-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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