Article
[DNA diagnosis of human cancers: lymphoid malignancies and leukemia].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Jan 1991
Takaku F
Abstract excerpt
Usefulness of DNA analysis in diagnosis of hematopoietic malignancy was discussed. Examination on the presence of rearrangement in immunoglobulin (Ig) and T cell receptor (TCR) was the first DNA analysis used for clinical diagnosis of lymphoid malignancy to determine the cell-lineage and clonality of proliferating lymphoid cells. One point mutation in ras oncogene has also been used to detect residual leukemic...
Topics
- Chromosome Fragility
- DNA, Neoplasm
- Gene Rearrangement
- Gene Rearrangement, T-Lymphocyte
- Genes, Immunoglobulin
- Genes, abl
- Genes, ras
- Humans
- Leukemia
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Lymphoma