Article
Transcriptional profiling reveals genes in the human pathogen Trichophyton rubrum that are expressed in response to pH signaling.
Microbial pathogenesis - 1 Feb 2010
Silveira Henrique C S, Gras Diana E, Cazzaniga Rodrigo A, Sanches Pablo R, Rossi Antonio, Martinez-Rossi Nilce M
Abstract excerpt
Trichophyton rubrum is a dermatophyte that infects human skin and nails. Its growth on keratin as its carbon source shifts the ambient pH from acidic to alkaline, which may be an efficient strategy for its successful infection and maintenance in the host. In this study, we used suppression subtractive hybridization to identify genes preferentially expressed in T. rubrum incubated at either pH 5.0 or pH 8.0. The...
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