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Retinoblastoma 1 Protein Modulates XY Germ Cell Entry into G1/G0 Arrest During Fetal Development in Mice1

29 Oct 2009

Abstract excerpt

During mouse germ cell development, the first sign of sex differentiation occurs when XY germ cells enter G(1)/G(0) arrest from 12.5 days postcoitum (dpc). Retinoblastoma 1 (RB1), a potent cell cycle regulator, was investigated in XY germ cell arrest by studying germ cell proliferation in Rb1(-/-) mutant mouse embryos. Because mice homozygous for the Rb1 deletion die in utero around 14.5 dpc, we used ex vivo...

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Identifiers

PMID: 19864318
DOI: 10.1095/biolreprod.109.078691

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