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Article

Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines.

Nature medicine - 1 Nov 2009

St John Ashley L, Abraham Soman N

Abstract excerpt

We report that infection of draining lymph nodes (DLNs) by Salmonella typhimurium results in the specific downregulation of the homeostatic chemokines CCL21 and CXCL13, which are essential for normal DLN organization and function. Our data reveal that the mechanism of this suppression is dependent on S. typhimurium LPS (sLPS). The decrease in CCL21 expression involves interaction between sLPS and CCL21-producing...

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Share to Acyltransferases
Share to Chemokines
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Salmonella Infections, Animal

Share to Smad3 Protein

Share to Suppressor of Cytokine Signaling 3 Protein

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Source

Open in PubMed Open full text

Identifiers

PMID: 19855398
DOI: 10.1038/nm.2036
PMCID: PMC3616497

Genes

CCL21
TLR4
CXCL13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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