Article
Selection, epistasis, and parent-of-origin effects on deleterious mutations across environments in Drosophila melanogaster.
The American naturalist - 1 Dec 2009
Wang Alethea D, Sharp Nathaniel P, Spencer Christine C, Tedman-Aucoin Katherine, Agrawal Aneil F
Abstract excerpt
Understanding the nature of selection against deleterious alleles is central to determining how populations are affected by the constant influx of new mutations. Important progress has been made in estimating basic attributes of the distribution of selection coefficients and gene interaction effects (epistasis). Although most aspects of selection are likely to be context dependent, little is known about the...
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