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Article

Patients with Leber hereditary optic neuropathy fail to compensate impaired oxidative phosphorylation.

Biochimica et biophysica acta - 1 Feb 2010

Korsten Alex, de Coo Irenaeus F M, Spruijt Liesbeth, de Wit L Elly A, Smeets Hubert J M, Sluiter Wim

Abstract excerpt

Ninety-five percent of Leber hereditary optic neuropathy (LHON) patients carry a mutation in one out of three mtDNA-encoded ND subunits of complex I. Penetrance is reduced and more male than female carriers are affected. To assess if a consistent biochemical phenotype is associated with LHON expression, complex I- and complex II-dependent adenosine triphosphate synthesis rates (CI-ATP, CII-ATP) were determined in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19836344
DOI: 10.1016/j.bbabio.2009.10.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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