Article
Association of polymorphisms of glutamate-cystein ligase and microsomal triglyceride transfer protein genes in non-alcoholic fatty liver disease.
Journal of gastroenterology and hepatology - 1 Feb 2010
Oliveira Claudia Pinto Marques Souza, Stefano José Tadeu, Cavaleiro Ana Mercedes, Zanella Fortes Maria Angela Henriques, Vieira Suzana Maria, Rodrigues Lima Vicência Mara, Santos Telma Eugenio, Santos Virginia Nascimento, de Azevedo Salgado Ana Lucia Farias, Parise Edson Roberto, Ferreira Alves Venâncio Avancini, Carrilho Flair José, Corrêa-Giannella Maria Lucia
Abstract excerpt
BACKGROUND AND AIMS: Although the metabolic risk factors for non-alcoholic fatty liver disease (NAFLD) progression have been recognized, the role of genetic susceptibility remains a field to be explored. The aim of this study was to examine the frequency of two polymorphisms in Brazilian patients with biopsy-proven simple steatosis or non-alcoholic steatohepatitis (NASH): -493 G/T in the MTP gene, which codes the...
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