Article
Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: a systems biology based approach.
Vision research - 31 Mar 2010
Silveira Alexandra C, Morrison Margaux A, Ji Fei, Xu Haiyan, Reinecke James B, Adams Scott M, Arneberg Trevor M, Janssian Maria, Lee Joo-Eun, Yuan Yang, Schaumberg Debra A, Kotoula Maria G, Tsironi Evangeline E, Tsiloulis Aristoteles N, Chatzoulis Dimitrios Z, Miller Joan W, Kim Ivana K, Hageman Gregory S, Farrer Lindsay A, Haider Neena B, DeAngelis Margaret M
Abstract excerpt
To identify novel genes and pathways associated with AMD, we performed microarray gene expression and linkage analysis which implicated the candidate gene, retinoic acid receptor-related orphan receptor alpha (RORA, 15q). Subsequent genotyping of 159 RORA single nucleotide polymorphisms (SNPs) in...
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