delta F508 deletion in cystic fibrosis in Italian families.

doi:10.1007/BF02428293

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Article

delta F508 deletion in cystic fibrosis in Italian families.

Human genetics - 1 Sept 1990

Restagno G, Garnerone S, Gennaro C, Varetto O, Ansaldi N, Castello D, Santini B, Carbonara A O

Abstract excerpt

In 20 Italian families with cystic fibrosis (CF), restriction fragment length polymorphisms were detected by five linked markers; a strong linkage disequilibrium is observed between the haplotype B (alleles 2/1 with respect to KM19/XV2c) and CF. The frequency of the delta F508 deletion in CF chro...

Topics

Cystic Fibrosis
Gene Frequency
Humans
Italy
Mutation
Polymorphism, Restriction Fragment Length

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