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Article

Novel variants near the central domain of RYR1 in two malignant hyperthermia-susceptible families from Taiwan.

Anesthesia and analgesia - 1 Oct 2009

Chen Po-Liang, Chang Yao-Wen, Chen Chun-Yu, Hsiang Yung-Chih, Day Yuan-Ji

Abstract excerpt

BACKGROUND: Our primary objective was to detect malignant hyperthermia (MH)-susceptible persons and thereby prevent MH episodes. We identified variants in the ryanodine receptor isoform 1 using molecular pedigree analysis. METHODS: Nineteen exons covering major hotspots were chosen for the primary screening by polymerase chain reaction, denaturing high performance liquid chromatography, and confirmed by direct...

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Source

Identifiers

PMID: 19762757
DOI: 10.1213/ane.0b013e3181ae94c7

Genes

RYR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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