Article
FHIT gene sequence variants and reduced Fhit protein expression in glioblastoma multiforme.
Cellular and molecular neurobiology - 1 Mar 2010
Cecener Gulsah, Tunca Berrin, Egeli Unal, Bekar Ahmet, Guler Gulnur, Tolunay Sahsine, Aksoy Kaya
Abstract excerpt
Molecular studies have an important role in the elucidation of the mechanisms involved in Glioblastoma multiforme (GBM) development. The occurrence of FHIT gene alterations, which has an important role in different cancers, has not yet been studied well in GBM. We aimed to investigate the occurrence of alterations of FHIT gene sequence and protein expression in the GBMs. Sequence alterations in exons 5-9 of the...
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