Article
Elevation of glutamine level by selenophosphate synthetase 1 knockdown induces megamitochondrial formation in Drosophila cells.
The Journal of biological chemistry - 20 Nov 2009
Shim Myoung Sup, Kim Jin Young, Jung Hee Kyoung, Lee Kwang Hee, Xu Xue-Ming, Carlson Bradley A, Kim Ki Woo, Kim Ick Young, Hatfield Dolph L, Lee Byeong Jae
Abstract excerpt
Although selenophosphate synthetase 1 (SPS1/SelD) is an essential gene in Drosophila, its function has not been determined. To elucidate its intracellular role, we targeted the removal of SPS1/SelD mRNA in Drosophila SL2 cells using RNA interference technology that led to the formation of vacuole-like globular structures. Surprisingly, these structures were identified as megamitochondria, and only depolarized...
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