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Article

Impaired prefrontal hemodynamic maturation in autism and unaffected siblings.

PloS one - 3 Sept 2009

Kawakubo Yuki, Kuwabara Hitoshi, Watanabe Kei-Ichiro, Minowa Michiko, Someya Toshikazu, Minowa Iwao, Kono Toshiaki, Nishida Hisami, Sugiyama Toshiro, Kato Nobumasa, Kasai Kiyoto

Abstract excerpt

BACKGROUND: Dysfunctions of the prefrontal cortex have been previously reported in individuals with autism spectrum disorders (ASD). Previous studies reported that first-degree relatives of individuals with ASD show atypical brain activity during tasks associated with social function. However, developmental changes in prefrontal dysfunction in ASD and genetic influences on the phenomena remain unclear. In the...

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Identifiers

PMID: 19727389
DOI: 10.1371/journal.pone.0006881
PMCID: PMC2731203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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