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Article

Genome-wide expression profile of LHON patients with the 11778 mutation.

The British journal of ophthalmology - 1 Feb 2010

Abu-Amero Khaled K, Jaber Mohammad, Hellani Ali, Bosley Thomas M

Abstract excerpt

AIM: To obtain a whole genome-expression profile in Leber hereditary optic neuropathy (LHON), patients with the 11,778 mitochondrial DNA mutation. METHODS: RNA was extracted from leucocytes and cDNA reverse-transcribed and hybridised to Affymetrix Gene Chips. A principal-component analysis and the rate monotonic algorithm were performed, and a further analysis applied to genes with a twofold expression difference...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19726426
DOI: 10.1136/bjo.2009.165571

Genes

OPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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