Article
Osteosarcoma originates from mesenchymal stem cells in consequence of aneuploidization and genomic loss of Cdkn2.
The Journal of pathology - 1 Nov 2009
Mohseny Alexander B, Szuhai Karoly, Romeo Salvatore, Buddingh Emilie P, Briaire-de Bruijn Inge, de Jong Daniëlle, van Pel Melissa, Cleton-Jansen Anne-Marie, Hogendoorn Pancras C W
Abstract excerpt
High-grade osteosarcoma is characterized by extensive genetic instability, thereby hampering the identification of causative gene mutations and understanding of the underlying pathological processes. It lacks a benign precursor lesion and reports on associations with hereditary predisposition or germline mutations are uncommon, despite the early age of onset. Here we demonstrate a novel comprehensive approach for...
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