Article
A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations.
Proceedings of the National Academy of Sciences of the United States of America - 8 Sept 2009
Joyner Alexander H, J Cooper Roddey, Bloss Cinnamon S, Bakken Trygve E, Rimol Lars M, Melle Ingrid, Agartz Ingrid, Djurovic Srdjan, Topol Eric J, Schork Nicholas J, Andreassen Ole A, Dale Anders M
Abstract excerpt
The gene MECP2 is a well-known determinant of brain structure. Mutations in the MECP2 protein cause microencephalopathy and are associated with several neurodevelopmental disorders that affect both brain morphology and cognition. Although mutations in MECP2 result in severe neurological phenotypes, the effect of common variation in this genetic region is unknown. We find that common sequence variations in a...
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