Article
A possible mechanism for the differences in efficiency and variability of active metabolite formation from thienopyridine antiplatelet agents, prasugrel and clopidogrel.
Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2009
Hagihara Katsunobu, Kazui Miho, Kurihara Atsushi, Yoshiike Michiharu, Honda Kokichi, Okazaki Osamu, Farid Nagy A, Ikeda Toshihiko
Abstract excerpt
The efficiency and interindividual variability in bioactivation of prasugrel and clopidogrel were quantitatively compared and the mechanisms involved were elucidated using 20 individual human liver microsomes. Prasugrel and clopidogrel are converted to their thiol-containing active metabolites through corresponding thiolactone metabolites. The formation rate of clopidogrel active metabolite was much lower and...
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