Article
Tissue biomarker development in a multicentre trial context: a feasibility study on the PETACC3 stage II and III colon cancer adjuvant treatment trial.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2009
Bosman Fred T, Yan Pu, Tejpar Sabine, Fiocca Roberto, Van Cutsem Eric, Kennedy Richard D, Dietrich Daniel, Roth Arnaud
Abstract excerpt
PURPOSE: We evaluated the feasibility of biomarker development in the context of multicenter clinical trials. EXPERIMENTAL DESIGN: Formalin-fixed, paraffin-embedded (FFPE) tissue samples were collected from a prospective adjuvant colon cancer trial (PETACC3). DNA was isolated from tumor as well as normal tissue and used for analysis of microsatellite instability, KRAS and BRAF genotyping, UGT1A1 genotyping, and...
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