Article
Calbindin-1 association and Parkinson's disease.
European journal of neurology - 1 Feb 2010
Soto-Ortolaza A I, Behrouz B, Wider C, Vilariño-Güell C, Heckman M G, Aasly J O, Mark Gibson J, Lynch T, Jasinska-Myga B, Krygowska-Wajs A, Opala G, Barcikowska M, Czyzewski K, Uitti R J, Wszolek Z K, Farrer M J, Ross O A
Abstract excerpt
BACKGROUND AND PURPOSE: Calcium levels have been proposed to play an important role in the selective vulnerability of nigrostriatal dopaminergic neurons in Parkinson's disease (PD). Recently, an association was reported between the calcium buffer, calbindin (rs1805874) and risk of PD in a Japanese patient-control series. METHODS: We genotyped rs1805874 in four independent Caucasian patient-control series (1543 PD...
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