Article
Influences on the reduction of relative telomere length over 10 years in the population-based Bruneck Study: introduction of a well-controlled high-throughput assay.
International journal of epidemiology - 1 Dec 2009
Ehrlenbach Silvia, Willeit Peter, Kiechl Stefan, Willeit Johann, Reindl Markus, Schanda Kathrin, Kronenberg Florian, Brandstätter Anita
Abstract excerpt
BACKGROUND: Telomeres play a key role in the maintenance of chromosome integrity. Short telomeres are linked to age-associated diseases and cancer. Our aim was to determine the decrease rate of relative telomere length (RTL) over 10 years and whether this rate was influenced by age, sex and smoking behaviour. METHODS: We compared RTL in 510 sample pairs from the longitudinal population-based Bruneck Study, which...
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