Article
Functional polymorphisms in matrix metalloproteinases -1, -3, -9 and -12 in relation to cervical artery dissection.
BMC neurology - 9 Aug 2009
Buss Armin, Pech Katrin, Roelver Susanne, Bloemeke Brunhilde, Klotzsch Christoph, Breuer Sebastian
Abstract excerpt
BACKGROUND: Cervical artery dissection is a leading cause of cerebral ischemia in young adults. Morphological investigations have shown alterations in the extracellular matrix (ECM) of affected vessel walls. As matrix metalloproteinases (MMP) play a central role in the regulation of the ECM, an increased expression of these enzymes might lead to the endothelial damage in spontaneous cervical artery dissection...
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