Article
[Biochemical markers of bone turnover. New aspect. Metabolic bone markers in osteogenesis imperfecta].
Clinical calcium - 1 Aug 2009
Tanaka Hiroyuki
Abstract excerpt
Osteogenesis imperfecta (OI) is a heterogeneous group of rare inherited bone and connective tissue disorders resulting from defect in collagen synthesis or function. It is characterized by bone fragility, which shows wide range of severities. The heterozygous mutations in the genes coding type I collagen are responsible to 80% of the OI cases. Metabolic bone markers relating type I collagen production or degraded...
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