Recent developments in osteogenesis imperfecta

Abstract excerpt

Osteogenesis imperfecta (OI) is an uncommon genetic bone disease associated with brittle bones and fractures in children and adults. Although OI is most commonly associated with mutations of the genes for type I collagen, many other genes (some associated with type I collagen processing) have now been identified. The genetics of OI and advances in our understanding of the biomechanical properties of OI bone are re...

Topics

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• Collagen Type I
• Connective tissue disorders research
• Extracellular Matrix
• Genetic Predisposition to Disease
• Metabolic Networks and Pathways
• Molecular Targeted Therapy
• Mutation
• Osteogenesis Imperfecta

Identifiers and source

Literature Corpus work

4446bb50-bcb5-52cd-a371-c3e2ace30260

DOI

10.12688/f1000research.6398.1