Adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes.

doi:10.3928/01477447-20090511-08

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Article

Adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes.

Orthopedics - 1 Jun 2009

Yang Yong, Wu Zhihong, Zhao Taimao, Wang Hai, Zhao Dong, Zhang Jianguo, Wang Yipeng, Ding Yaozhong, Qiu Guixing

Abstract excerpt

The etiology of adolescent idiopathic scoliosis is undetermined despite years of research. A number of hypotheses have been postulated to explain its development, including growth abnormalities. The irregular expression of growth hormone and insulin-like growth factor-1 (IGF-1) may disturb hormone metabolism, result in a gross asymmetry, and promote the progress of adolescent idiopathic scoliosis. Initial...

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PMID: 19634821
DOI: 10.3928/01477447-20090511-08

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.