Article
Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in the testis.
Journal of human genetics - 1 Aug 2009
Sugimoto Kazuhiro, Koh Eitetsu, Sin Ho-Su, Maeda Yuji, Narimoto Kazutaka, Izumi Koji, Kobori Yoshitomo, Kitamura Eiko, Nagase Hiroki, Yoshida Atsumi, Namiki Mikio
Abstract excerpt
Numerous CpG islands containing tissue-specific differentially methylated regions (TDMRs) are potential methylation sites in normal cells and tissues. The VASA (also known as DDX4) gene is believed to be under the control of TDMRs. A total of 131 male patients with idiopathic azoospermia or severe oligospermia were evaluated histologically, and the methylation status of CpG islands in the VASA gene was screened....
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