Article
Acanthosis nigricans and insulin sensitivity in patients with achondroplasia and hypochodroplasia due to FGFR3 mutations.
The Journal of clinical endocrinology and metabolism - 1 Oct 2009
Alatzoglou Kyriaki S, Hindmarsh Peter C, Brain Caroline, Torpiano John, Dattani Mehul T
Abstract excerpt
BACKGROUND AND AIMS: Acanthosis nigricans (AN) has been reported in association with severe skeletal dysplasias due to activating mutations in FGFR3, including thanatophoric dysplasia, severe achondroplasia (ACH) with developmental delay and AN (SADDAN syndrome), and Crouzon syndrome with AN. There are isolated reports of patients with ACH and AN. In this series, we report clinical and biochemical data on five...
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